Batwoman - real name Kathy Kane - will appear in 52, a year-long DC Comics publication that began this month.
In her latest incarnation, she is a rich socialite who has a romantic history with another 52 character, ex-police detective Renee Montoya.
52 will be published in the UK as a graphic novel by Titan Books in 2007.
The series is set in a world in which established superheroes Batman, Superman and Wonder Woman do not play a part.
The new-look Batwoman is just one of a wave of ethnically and sexually diverse characters entering the DC Comics universe.
Others include Mexican teenager Blue Beetle - who replaces the character's previous white incarnation - and the Great Ten, a government-sponsored team of Chinese superheroes.
Regular characters Firestorm and The Atom, meanwhile, have been reinvented as black and Asian heroes respectively.
The characters are part of a wider effort to broaden the make-up of comic-book creations in line with society as a whole.
Batwoman, who first appeared in July 1956, has not been seen since September 1979 when she was killed by the League of Assassins and the Bronze Tiger.